Its about time I wrote about them as they have been quite a focus.
There seems to have been four stages.

1. Before I noticed the haematuria it felt more like a case of bloat after eating too much, which to some degree it was. However it wasn't the full story.
2. Then for a short period they became more butterfly like and were accompanied by a slight disorientation, and followed by obvious gross haematuria.
3. Next followed the prolonged period of some two months or more of a cold feeling just about and maybe to the left of the bladder area. A bit as if maybe some nerves were healing. Although it would come and go, almost in sync with eating it didn't sync with any passing of blood visible or otherwise. It conveniently started just around the time I started using herbs, although I can't really ally it to that . It also stopped a day or two before I finished a specific TCM, some three or four days ago.
4. So now I'm in a stage where it's infrequent as I though there was an odd lighter feeling, only once or twice since

July 7th
Just a short note to say the twinges are fairly evident lots of the time but as noted about they are not the cold ones I used to have. I'm also not drinking at all so I'd better change that and see what happens.

Link only so far:

Pifubing Xuedu Wan

Radix Rubiae
Herba Schizonepetae
Fructus Xanthi
Herba Leonuri
Fructus Arctii
Radix Glycyrrhizae
Radix Angelicae Dahuricae
Rhizoma Ligustici Chuanxiong
Flos Carthami

From: topherb.co.uk
Paeonia lactiflora root; Imperata cylindrica rhiz; Rehmannia glutinosa root; Paeonia veitchii root; Ledebouriella divaricata root; Arctium lappa fruit; Ligusticum wallichii rhiz; Rubia cordifolia root; Juglans regia seed; Schizonepeta tenuifolia herb; Angelica acutiloba root; Kochia scoparia fruit; Xanthium sibiricum fruit; Forsythia suspensa fruit; Lonicera japonica flower bud; Corydalis bungeana herb; Smilax glabra rhiz; Gleditsia Australis thorn; Platycodon grandiflorum root; Leonurus sibiricus herb; Paeonia suffruticosa root bark; Dictamnus desycarpus root; Rheum palmatum root & rhiz; Glycyrrhiza uralensis root & rhiz; Angelica dahurica root; Spatholobus suberectus stem; Sempervivum tectorum herb; Lonicera japonica stem; Arnebia euchroma root; Carthamus tinctorius; flower Spirodela polyrrhiza herb.

20th June 09:30
Yesterday I spoke to Dr M as I gathered she had the results of the cytology tests. Two of the three ’showed indications of transitional cell carcinoma’.

Draft ideas to present to 'Statutory Health Professionals'

How significant is the indication is that either the haematuria has stopped or just about so?

The first issue is that I wasn't able to monitor events earlier as a) I wasn't aware that there could have been a problem for possibly six months prior to the obvious; b) once there was a visual indication I thought the first two instances could just be anomalies from strain; and c) when I did approach the GP she was against my self-monitoring.

I see no reason why people should be discouraged from self monitoring, and the cost of 10p per week can hardly be a legitimate reason not to object. Urine testing can expose a substantial range of metabolic imbalances or abnormalities. Once a person finds an anomaly they could then monitor daily. On approaching a GP for assistance then everything possible should be done to help the 'patient' (bad word) investigate and or monitor their condition.

As far as my personal condition goes, I'm waiting at least until the end of the month so I can show a months results of little or no haematuria. That there is some, is only notable as I have testing sticks indicating that, which would otherwise go unnoticed to the unaided eye.

Without the test sticks I would have no idea of what is going on.

My 'worry' now is not that I may have any obvious haematuria indicating a continued or increased physiological damage, but that even a few cells could indicate an unwanted turn of events. I haven't found data on urine samples in either a haematuric or a 'clean urine' situation.

At least the data I am gathering may be of some use even if the situation deteriorates.

I have created a graph, spanning 3 months with a backward projection indicating the level of haematuria for fortnightly periods. Both exponential and logarithmic trends are optimistic.

However I can see the reluctance of any GP to be unimpressed, and for their professional standing would like to have further information via cystoscopy. Their requirement to maintain a professional standing does not necessarily equate to the best procedure, just the commonly accepted one.

I am not a slave to the health professionals and their insistence on an invasive procedure is largely authoritarian. Until their desire to investigate equates to mine their use of "we need to get to the bottom of this'' or "this doesn't help us" is just bullying. There is no 'we' or 'us' in present situation. I am gathering information so I can acquaint myself with my body. Without a satisfactory and common knowledge there can be no agreement on what action would enhance this diagnosis.

Statistical evidence is the method by which common procedure are agreed, and yet I see no evidence that my analysis is spurious to the investigation. Only further monitoring and evidence would provide enough statistics to show that such an investigative method would be useful in diagnosis.

On the graph below, apart from the obvious and substantially progressive decline, the notable points are:

1. The red horizontal line indicates the theoretical maximum that the urine testing sticks can define, at approx 200 cells/µlt
2. At 300 cells/µlt the blood may be visible??
3. The blue mark and blue hatched area is an estimate of the average for the two week period before I acquired the testing sticks. The figure if anything is more likely to be on the low side.
4. Exponential projections would never reach zero, and the logarithmic projection indicates complete cessation at the beginning of June, which is much the case.

 

 

Coumarin: C₉H₆O₂

From: wikipedia.org

Coumarin is a chemical compound (benzopyrone); a toxin found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has a sweet scent, readily recognised as the scent of newly-mown hay, and has been used in perfumes since 1882. It has clinical medical value as the precursor for several anticoagulants, notably warfarin, and is used as a gain medium in some dye lasers. The name comes from a French word, coumarou, for the tonka bean.

From: www.biologie.uni-hamburg.de

"Glycosides, or sugar ethers, are a complex grouping which can be broken down to yield one or more sugars (glycones), plus a non-sugar component (aglycones)."

"Some phytochemical groups, such as anthraquinone phenols, normally do contain glycosides, so they are nicknamed anthraquinone glycosides."

anthraquinone glycosides, nown primarily for their laxative actions, were found after the aglycones (a non-sugar component) of anthraquinones had been obtained upon hydrolysis. Both glycones and aglycones of anthracene derivation are polyphenols containing the red or purple pigment found in senna, cascara, rheum, and aloe, for example."

Flavonoid glycosides are yellow pigments in flowers and plants which have demonstrated antiinflammatory, anti-allergic effects, antithrombotic and vasoprotective properties. These plant constituents exert antioxidant effects on free radicals in the body. Related to flavonoid glycosides are the anthocyanidins and anthocyanins, mentioned under the phenol heading.

Lactone glycosides, a.k.a. Coumarin glycosides are very fragrant: they are the source, for instance, of freshly-mown hay scents (ibid.). Medicinally, coumarin glycosides have been shown to have hemorrhagic, antifungicidal, and antitumor activities. The lactone glycoside dicumarol is known as an anticoagulant.

Cyanogenic glycosides, which initially contain hydrogen cyanide (HCN) compounds, are toxic to unadapted farm animals and humans. However, some have been found to be of cytotoxic interest in cancer research. Originally, these glycosides were probably developed so that a plant could defend itself from herbivores. The cyanide content, referred to as a bound toxin, only occurs in some of the 1000 or so plants which initially produce cyanohydrin upon hydrolysis (Harborne and Baxter, 84). Detection of the presence of cyanide is accomplished through smell or by its yellow to brownish-red reaction with moist picrate paper. Prunasin, to illustrate, is a cyanogenic glycoside occurring in Wild Cherry Bark, a botanical which has been used since the late 1700's as a cough sedative and medicinal flavorant (Evans, 538). Diagnostic caution: if the amygdalin is present with benzaldehyde following hydrolysis, the agent is an aldehyde glycoside.

From: wikipedia

Anthraquinone glycosides

These glycosides contain an aglycone group that is a derivative of anthraquinone. They are present in senna, rhubarb and aloes; they have a laxative effect.

Coumarin glycosides

Here the aglycone is coumarin. An example is apterin which is reported to dilate the coronary arteries as well as block calcium channels.those obtained from dried leaves of Psoralia corylifolia have Main glycosides psoralin and corylifolin.

Cyanogenic glycosides

In this case, the aglycone contains a cyanide group, and the glycoside can release the poisonous hydrogen cyanide if acted upon by some enzyme. An example of these is amygdalin from almonds. Cyanogenic glycosides can be found in the fruits (and wilting leaves) of the rose family (including cherries, apples, plums, almonds, peaches, apricots, raspberries, and crabapples). Cassava, an important food plant in Africa and South America, contains cyanogenic glucosides and therefore has to be washed and ground under running water prior to consumption.

Local species of the tribe Stellateae

Following the article "Galiosinase in the Shoots of Stellateae", appended, I am investigating the following species.

1. Cleavers: Galium aparine
2. Hedge Bedstraw: Galium mollugo
3. Woodruff: Galium odorata

I am gathering and drying both the first two above and storing separately their leaves and stems. In the case of cleavers the stem seems to have more coumarin as it makes a slightly reddish-brown brew and tastes distinctly rich.

Since finding info on 'coumarin' see link above, I am will be looking out for 'Woodruff' whilst Mullein. mullein does grow here.

 
Hedge Bedstraw: Galium mollugo Easily reaching 4 feet on occasion.

 

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Glycosidase Galiosinase in the Shoots of Stellateae
A. R. TRIM Biochemical Laboratory Cambridge

. . .
3. The distribution of the enzyme in the shoots of 14 species of Stellateae, representing genera, has been investigated.
4. In the leaves and stem galiosinase occurs in high concentrations in the cambium and in lower concentrations in the developing phloem and xylem.
5. In some parts of the stem near the base of the shoot and at the nodes the enzyme may also occur in the medulla and cortex.
6. When galiosinase occurs outside the cambium it may be accompanied by its specific substrates, the glucoside and primveroside of purpurin-3-carboxylic acid.
7. In the parts which accumulate the purpurin-3-carboxylic acid glycosides there is an approximately direct proportionality between the concentrations of enzyme and glycoside.
8. When kept in water for a few days the excised leaves and stems of some species produce large amounts of galiosinase.
9. The formation of enzyme in excised parts is closely followed by the accumulation of purpunn-3-carboxylic acid glycosides.
. . .